Colonization of Germ-free Transgenic Mice with Genotyped Helicobacter pylori Strains from a Case-Control Study of Gastric Cancer Reveals a Correlation between Host Responses and HsdS Components of Type I Restriction-Modification Systems*□S
نویسندگان
چکیده
From the ‡Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, Missouri 63110, the §Department of Medicine, Karolinska Institute, 171 77 Stockholm, Sweden, the ¶Department of Microbiology and Immunology, Stanford University, Stanford, California 94305, ‡‡Swedish Institute for Infectious Disease Control, 171 82 Solna, Sweden, and §§AstraZeneca Research and Development, 431 83 Mölndal, Sweden
منابع مشابه
Colonization of germ-free transgenic mice with genotyped Helicobacter pylori strains from a case-control study of gastric cancer reveals a correlation between host responses and HsdS components of type I restriction-modification systems.
Helicobacter pylori infects the stomachs of half of all humans. It has a relatively benign relationship with most hosts but produces severe pathology, including gastric cancer, in others. Identifying the relative contributions of host, microbial, and environmental factors to the outcome of infection has been challenging. Here we describe one approach for identifying microbial genes that affect ...
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